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Therefore, DPP-IV inhibitors raise levels of endogenous GLP-1(7–36)amide, and it could be that at clinically relevant doses, this action of DPP-IV inhibitors produces a relatively selective increase of GLP-1(7–36)amide in the hepato-portal circulation or at the interface of L cells and vagal sensory nerve terminals

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This ensures the program aligns with your specific requirements and addresses potential risks