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Cardiovascular Outcomes Following Ertugliflozin Treatment in Type 2 Diabetes Mellitus Participants with Vascular Disease (VERTIS-CV), which compared ertugliflozin with placebo showed non-inferiority in regards to its primary MACE outcome, as well as a 30% reduction in HHF [41]
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Another LoF variant, R421W, displays reduced coupling to mini-Gα s proteins in response to various endogenous and clinical agonists (Lagou et al., 2021)
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